Inhibitory effect of total flavones of Metasequsia glytostroboides on platelet aggregation and hemarheology in rats and mechanism research
- Author:
Ying AO
1
Author Information
1. Dept. of Pharmacology, Medical College of Wuhan University
- Publication Type:Journal Article
- Keywords:
5-HT releasement;
Hemarheology;
NO;
Platelet aggregation;
Total flavones of Metasequsia glyptostrobiodes (FMG)
- From:
Chinese Pharmacological Bulletin
2002;18(2):214-217
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effects of total flavones of Metasequsia glytostroboides Hu et Cheng (FMG) on platelet aggregation, 5-HT release, NO contents of plasma and hemarheology in rats. METHODS: Platelet aggregation was quantified by turbidimetric method. 5-HT release was assayed by fluorescence technique. NO content of plasma was assayed by spectrophotometry. RESULTS: FMG inhibited the platelet aggregation and 5-HT release, increased the NO content of plasma, decreased the whole blood viscosity, plasma viscosity, eryrocyte electrophoresis time, K value of erythrocyte sedimentation equation and RBC, improved the hemarheology of rats. CONCLUSION: FMG can inhibit the platelet aggregation and improve the hemarheology in rats. The inhibition on 5-HT release, increase of NO contents of plasma and the inhibitory effect on Ca2+ may be its mechanisms.
