Effects of thymectomy on glucose metabolism in rats and modulation of rehmannia glutinosa oligosaccharides on glucose metabolism in thymectomized rats
- Author:
Ru-Xue ZHANG
1
Author Information
1. Base of Clinical Pharmacology, Lanzhou General Hospital of PLA
- Publication Type:Journal Article
- Keywords:
Blood glucose;
Glucose metabolism;
Insulin;
Liver glycogen;
Rehamannia glutinosa oligosaccharides;
Thymectomy
- From:
Chinese Pharmacological Bulletin
2002;18(2):194-197
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the changes of blood glucose level, plasma insulin level and liver glycogen content and regulatory effects of rehmannia glutinosa oligosaccharides (ROS) on glucose metabolism in thymectomized rats. METHODS: 1) Plasma glucose level, liver glycogen content and plasma insulin level of thymectomized rats were determined three, four, eight and fifteen month after thymectomy operation; 2) Effects of ROS (250 mg·kg-1, po, × 60 d) on spleencyte proliferation, blood glucose level, liver glycogen content, plasma insulin level and plasma corticosterone level in thymectomized rats were investigated seven month after thymectomy. RESULTS: From 8 months after thymectomy liver glycogen content and plasma insulin level increased in thymectomized rats, though no obvious changes in blood glucose level were found during the experiment; 2) Changes of glucose metabolism in thymectomized rats were largely reversed and normalized with ROS: Increased liver glycogen content turned to be normal, increased plasma insulin level, decreased corticosterone level and decreased splenocyte proliferation in thymectomized rats became normal. CONCLUSION: Some changes in glucose metabolism are induced by thymectomy in rats, which can be largely reversed by ROS.
