The inhibitory effect of tamoxifen on the proliferation of the anterior pituitary cell of rats
- Author:
Yu-Zhen HU
1
Author Information
1. Dept. of Physiology, Fourth Military Medical University
- Publication Type:Journal Article
- Keywords:
Apoptosis;
Estrogen;
Pituitary;
Tamoxifen
- From:
Chinese Pharmacological Bulletin
2002;18(2):187-189
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of tamoxifen on the proliferation of the anterior pituitary cell of rats and its mechanism. METHODS: Primary culture of the anterior pituitary cell of rats and 3HTdR incorporation method were applied. The changes of cell morphology were observed directly by electric microscope. RESULTS: Tamoxifen could inhibit the proliferation of the anterior pituitary cell of rats. The inhibitory effect of tamoxifen (0.1 μmol·L-1) could be reversed by estrogen. The classical apoptotic changes appeared in the cells after tamoxifen incubation for 48 h. CONCLUSION: Tamoxifen can inhibit the proliferation of the anterior pituitary cell of rats and resultin the cell apoptosis.
