Effects of polysaccharides from cryptoporus volvatus(peck) schear on leukotrienes generation in guinea pig lung
- Author:
Jian-Cang ZHOU
1
Author Information
1. Zhejiang Resp. Drugs Res. Laboratory, State Drugs Administration of China, Med. School of Zhejiang University
- Publication Type:Journal Article
- Keywords:
Cryptoporus volvatus;
Guinea pig;
Leukotriene D4(LTD4);
Lung;
Polysaccharides;
Reversed phase high-performance liquid chromatography (RP-HPLC);
Slow reacting substance of anaphylaxis (SRS-A)
- From:
Chinese Pharmacological Bulletin
2002;18(2):169-172
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effects of polysaccharides of ferment cultured cryptoporus volvatus (CVPS) on release of leukotrienes from guinea pig lung and Schultz - Dale reaction. METHODS: The bioassay method and reversed phase high-performance liquid chromatography (RP-HPLC) were used to analyze SRS-A or LTD4 from sensitized or normal guinea pig, after challenged with antigen or A23187 respectively. The antiallergic effects of CVPS were evaluated with Schultz-Dale reaction. RESULTS: The release of SRS-A or LTD4 from sensitized or normal guinea pigs were greatly reduced by CVPS after antigen or A23187 challenge. The CVPS could also inhibit the Schultz-Dale reaction of sensitized guinea pig (IC50 = 0.49 g·L-1). CONCLUSION: The effects of CVPS involved in inhibiting release of leukotrienes from lung and antiallergy.
