Effects of Bombina maxima protein on growth of bladder cancer cell lines and expession of telomerase
- Author:
Ji-Hong SHEN
1
Author Information
1. Dept. of Urology of Huaxi Hospital, Sichuan University
- Publication Type:Journal Article
- Keywords:
Bladder cancer cell lines;
Bombina maxima;
Serine protease inhibitor;
Telomerase
- From:
Chinese Pharmacological Bulletin
2002;18(2):136-138
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the boosting effect of Bombina maxima protein on bladder cancer cell lines growth and expression of telomerase. METHODS: Cell culture was used to dectect the effects of 3 blad der cancer cell lines growth; TRAP-PCR-ELISA method was used to detect the telomerase express under the ID50 culture concentration. RESULTS: Bombina maxima protein had the strong effect on growth of cell lines; particularly in the first 48 h; no effect was found in telomerase expression. CONCLUSION: Bombina maxima protein has the direct inhibitory effect on bladder cancer cell lines growth; The mechanism of antitumor of Bombina maxima protein is not by telomerase.
