TLR4-MD2 signaling pathway induced by endotoxin
- Author:
Yong-Wang LI
1
Author Information
1. Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University
- Publication Type:Journal Article
- Keywords:
Inflammation;
Lipopolysaccharide;
Signal transduction
- From:
Chinese Pharmacological Bulletin
2002;18(2):121-125
- CountryChina
- Language:Chinese
-
Abstract:
Recent evidence suggests Toll-like receptor 4 (TLR4) and its accessory protein MD2 mediate endotoxin/lipopolysaccharide (LPS) signaling. LPS binds to LPS binding protein (LBP) in plasma and is delivered to CD14. Next, LPS is transferred to TLR4-MD2 complex. LPS activates several intracellular signaling pathways that include the NF-κB pathway and three mitogen-activated peotein kinase (MAPK) pathway: extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38. These signaling pathways in turn activate NF-κB and AP-1 (c-fos/c-jun), which coordinate the induction of many genes encoding inflammatory mediators. Targeting the signaling molecule in the pathway will develop new remedies for treatment of inflammatory disorder.
