A mouse model of capsaicin-induced cough and a record device for cough
- Author:
Kang-Song WU
1
Author Information
1. Zhejiang Resp. Drugs Res. Laboratory, State Drugs Administration of China, Med. School of Zhejiang University
- Publication Type:Journal Article
- Keywords:
Animal model;
Capsaicin;
Codeine;
Cough;
Ephedrine;
Mouse
- From:
Chinese Pharmacological Bulletin
2002;18(1):109-111
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To establish a mouse model of capsaicin-induced cough and a record device for cough. METHODS: The cough reflect in mice was induced with 0.l mmol·L-1 capsaicin by aerosol, and the number of cough was recorded by a Medlab system. RESULTS: The number of cough in mice after provoked by capsaicin aerosol was 16.8 ± 5.0 (n = 65) within 3 min. The cough reflect was inhibited by codeine pretreatment ig. ID50 values (95% confidence limits) of codeine was 9.69 (7.56 - 12.42) mg · kg-1. While pretreatment with ephedrine, a non-antitussive drug, 2.0 and 4.0 mg · kg-1 ig had no inhibitory effect. CONCLUSION: Capsaicin-induced cough model of mouse is a useful antitussive drugs screening model. The result of experiment objectively can be observed by the cough record device.
