Effect of l-menthol pretreated nasal cavity on insulin pharmacological bioavailability
- Author:
Hui WANG
1
Author Information
1. Dept. of Pharmacology, Guangdong Medical College
- Publication Type:Journal Article
- Keywords:
Blood glucose;
Insulin;
l-menthol;
Nasal cavity absorption;
Pharmacological bioavailability(PBA)
- From:
Chinese Pharmacological Bulletin
2002;18(1):64-66
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect l-menthol pretreated nasal cavity on insulin pharmacological bioavailability(PBA). METHODS: To set up diabetic rats model, nasal cavities were pretreated with l-menthol for two hours, insulin was dripped, blood glucose concentrations of different time were determined, and the area over the curve (AOC) and pharmacological bioavailability (PBA) were calculated. RESULTS: After rats nasal cavity was pretreated with different concentrations l-menthol, nasal cavity absorption of insulin markedly increased between 2 h and 3 h, and PBA of insulin nasal cavity absorption increased respectively 5.77, 7.00 and 3.12 times than control group. CONCLUSION: l-Menthol promotes the nasal cavity absorption of insulin.
