Research progress of protein kinase C-zeta
- Author:
Duan-Fang LIAO
1
Author Information
1. Inst. of Pharmacy and Pharmacology, Nanhua University
- Publication Type:Journal Article
- Keywords:
Protein kinase C-zeta;
Signal transduction;
Structure and function
- From:
Chinese Pharmacological Bulletin
2002;18(1):13-16
- CountryChina
- Language:Chinese
-
Abstract:
Protein Kinase C-zeta (PKC-ζ) is a new member of protein kinase C family and has some specific characteristics as comparing with the classical PKC. It lacks the C2 domain making its kinase activity Ca2+ -independent, and it possesses only one zinc-finger region in its regulatory domain. Therefore, PKC-ζ does not bind Ca2+ and can not be activated by diacylglycerol or phorbol esters. In addition, many researches showed that PKC-ζ could induce differentiation, mediate insulin-stimulation protein synthesis, activate immunity of human neutrophils, inhibit proliferation of cancer cells and regulate the function of actin cytoskeleton. What is more, PKC-ζ plays an important role in signal transduction of cells, such as mediating MAPK and NF-κB activation.
