A study on the antibacterial activity of cefathiamidine combined with ciprofloxacin against Gram-positive cocci
- Author:
Dong CHAI
1
Author Information
1. Chinese PLA General Hospital
- Publication Type:Journal Article
- Keywords:
Cefathiamidine;
FIC;
Gram-positive cocci
- From:
Chinese Pharmacological Bulletin
2005;21(1):117-119
- CountryChina
- Language:Chinese
-
Abstract:
Aim: To study the in virto interaction of Cefathiamidine in combination with Ciprofloxacin against clinical isolates of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis. Methods: The activity of each drug alone was determined against all the isolates. Chequerborad synergy testing was then performed against all the isolates. Results: The percentage of the FIC index less than 0.5, from 0.5 to 1, from 1 to 2, more than 2 was 53.3% - 93.3%, 6.7% - 46.7%, 0%, 0% respectively. Conclusion: Synergism and additivity of cefathiamidine combined with ciprofloxacin respectively against 90 strains of Gram positive cocci were the main inter actions, there were little autonomy and no antagonism.
