Study on amelioration of aminoguanidine on diabetic neuropathy and its mechanism
- Author:
Zai CHANG
1
Author Information
1. Dept. of Pharmacology, Marine Drug Research Center, Nanjing University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
AGEs;
Aminoguanidine;
Db/db mouse;
Diabetic neuropathy
- From:
Chinese Pharmacological Bulletin
2005;21(1):103-105
- CountryChina
- Language:Chinese
-
Abstract:
Aim: To determine whether aminoguanidine increases the motor neve conduction velocity of db/db mice and why. Mothods: Motor neve conduction velocity was assayed by Powerlab/8s multipurpose physiological recorder. Advanced glycosylation end products of db/db mice kidney were determined by fluorometer. Results Motor neve conduction velocity of 6 months db/db mice treated with Aminoguanidine for 5 months increased significantly. Conclusion: Aminoguanidine can prevent the decrease of the motor neve conduction velocity of db/db mouse by decreasing the advanced glycosylation end products.
