Ca2+ sparks in cardiac myocytes
- Author:
Guang-Qin ZHANG
1
Author Information
1. Research Division of Pharmacology, China Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
Ca2+ sparks;
Cardiac myocytes
- From:
Chinese Pharmacological Bulletin
2005;21(1):23-26
- CountryChina
- Language:Chinese
-
Abstract:
In cardiac myocytes, Ca2+ sparks origining from a single RyR or a few RyRs are triggered by a single L-type Ca2+ channel or occur spontaneously. Ca2+ sparks constitute the elementary local Ca 2+ release events from the SR. Ca2+ sparks occur at Z-lines and randomly distribute at different locations, the characteristics of the kinetics are regulated by many factors. In addition, ICa.T, Na+/Ca2+ exchange, ICa (TTX) and IP3 are other putative sources of Ca2+ that trigger SR Ca2+ release.
