Research progress of endothelial mesenchymal transition in myocardial fibrosis
10.3969/j.issn.1001-1978.2019.01.004
- Author:
Yu-Jie YIN
1
Author Information
1. Graduate School, Hebei University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Chronic heart failure;
Endothelial cells;
Endothelial mesenchymal transition;
Myocardial infarction;
Signaling pathways;
Tcf-0
- From:
Chinese Pharmacological Bulletin
2019;35(1):12-16
- CountryChina
- Language:Chinese
-
Abstract:
Endothelial mesenchymal transition ( EndMT) , a biological process in which endothelial cells under specific environmental stimuli, gradually lose close connection and expression of specific markers, and obtain stromal cells or muscle fiber cell plienolypic expression and characteristics of movement and shrinkage. EndMT not only plays a crucial role in the development of heart and vascular, but lias been widely studied in the process of organ fibrosis such as heart, lung and kidney. It may be the key step in the prevention and treatment of myocardial fibrosis. We review the research progress of EndMT in myocardial fibrosis.
