Effects of intestinal microflora on drug metabolism
10.3969/j.issn.1001-1978.2019.02.005
- Author:
Yu-Yan CHEN
1
Author Information
1. College of Pharmacy, Ningxia Medical University
- Publication Type:Journal Article
- Keywords:
Drug metabolism;
Flora classification;
Flora function;
Intestinal flora;
Plateau hypoxia;
Rational administration
- From:
Chinese Pharmacological Bulletin
2019;35(2):168-172
- CountryChina
- Language:Chinese
-
Abstract:
A large number of gut flora communities have colonized in the intestine, which is crucial to the metabolism of foreign compounds such as drugs. In recent years, the gut flora has been widely regarded as the "invisible organ" of the body. By reviewing the pertinent literature at home and abroad, classifications and functions of intestinal flora and its influence on the chemical composition and chemical metabolism of Chinese medicine are analyzed in the article. Understanding the impact of intestinal flora on drug metabolism and the process of drug conversion has great significance in guiding clinical rational drug use and individual therapy, evaluating toxicity and promoting drug discovery and development, and providing theoretical guidance for the study of the effects of intestinal flora on drug metabolism in the plateau environment.
