The research progress on relationship between depression and chemokines
10.3969/j.issn.1001-1978.2019.05.006
- Author:
Qing-Lian ZHENG
1
Author Information
1. Institute for Brain Research and Rehabilitation, South China Normal University
- Publication Type:Journal Article
- Keywords:
Chemokine receptors;
Chemokines;
Depression;
Inflammation;
Microglia cells;
Neuron;
Neuroplasticity
- From:
Chinese Pharmacological Bulletin
2019;35(5):615-619
- CountryChina
- Language:Chinese
-
Abstract:
Inflammation is an important mechanism and etiology of depression. In recent years, researchers have demonstrated that many depression patients are with inflammatory reactions in the corresponding brain regions, and simultaneously chemokines play an important role in depression and inflammation. Meanwhile , in the course of depression, chemokines and their receptors are involved in neuroplasticity, the decrease of monoamine neurotransmitters and neuroendocrine system. In this review, in order to further understand and find better treatment of depression, we summarize the recent studies of the relationship between chemokines and depression disorder.
