Research progress of nlrp3 inflammasome in diabetic cardiomyopathy
10.3969/j.issn.1001-1978.2019.08.004
- Author:
Xue-Lian LI
1
Author Information
1. First Affiliated Hospital of Nanchang University, Dept of Cardiology
- Publication Type:Journal Article
- Keywords:
Autophagy;
DCM;
Nf-kb;
Nlrp3;
Oxidative stress;
Reactive oxygen species
- From:
Chinese Pharmacological Bulletin
2019;35(8):1051-1054
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cardiomyopathy( DCM) is one of the important cardiovascular complications of diabetes mellitus. Metabolic disorders, mitochondrial damage, cardiomyocyte apoptosis and autophagy are involved in the development of DCM. Recent research demonstrates that NLRP3 inflammasome plays a vital role in the pathogenesis of DCM, and has emerged as a potential tar get for the treatment of DCM. In this article, research progress in NLRP3 inflammasome and DCM has been reviewed, aiming to provide novel therapeutic idea for the treatment of DCM.
