Genetic Variants in the Wnt Signaling Pathway Are Not Associated with Survival Outcome of Non-Small Cell Lung Cancer in a Korean Population.
10.3346/jkms.2016.31.3.463
- Author:
Seung Soo YOO
1
;
Mi Jeong HONG
;
Jin Eun CHOI
;
Jang Hyuck LEE
;
Sun Ah BAEK
;
Won Kee LEE
;
So Yeon LEE
;
Shin Yup LEE
;
Jaehee LEE
;
Seung Ick CHA
;
Chang Ho KIM
;
Sukki CHO
;
Jae Yong PARK
Author Information
1. Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. jaeyong@knu.ac.kr
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
WNT;
Lung Neoplasms;
Polymorphisms;
Survival
- MeSH:
Aged;
Asian Continental Ancestry Group/*genetics;
Carcinoma, Non-Small-Cell Lung/*genetics/mortality/pathology;
Demography;
Disease-Free Survival;
Female;
Genotype;
Humans;
Kaplan-Meier Estimate;
Lung Neoplasms/*genetics/mortality/pathology;
Male;
Middle Aged;
*Polymorphism, Single Nucleotide;
Republic of Korea;
Smoking;
Wnt Signaling Pathway/*genetics
- From:Journal of Korean Medical Science
2016;31(3):463-466
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recently, genetic variants in the WNT signaling pathway have been reported to affect the survival outcome of Caucasian patients with early stage non-small cell lung cancer (NSCLC). We therefore attempted to determine whether these same WNT signaling pathway gene variants had similar impacts on the survival outcome of NSCLC patients in a Korean population. A total of 761 patients with stages I-IIIA NSCLC were enrolled in this study. Eight variants of WNT pathway genes were genotyped and their association with overall survival and disease-free survival were analyzed. None of the eight variants were significantly associated with overall survival or disease-free survival. There were no differences in survival outcome after stratifying the subjects according to age, gender, smoking status, and histological type. These results suggest that genetic variants in the WNT signaling pathway may not affect the survival outcome of NSCLC in a Korean population.
