Research progress of PTP1B in common tissue inflammation
10.3969/j.issn.1001-1978.2019.10.005
- Author:
Lei YANG
1
Author Information
1. School of Pharmacy, Anhui Medical University, Anhui Key Lab of Natural Drug Activity Research, Anhui Province Key Lab of Major Autoimmune Diseases
- Publication Type:Journal Article
- Keywords:
Inflammation;
Macrophages;
Mechanism;
PTP1B;
PTPs;
Structure
- From:
Chinese Pharmacological Bulletin
2019;35(10):1350-1353
- CountryChina
- Language:Chinese
-
Abstract:
Protein tyrosine phosphatase 1B (PTP1B) belongs to the protein tyrosine phosphatase superfamily, which can dephosphoiylate protein tyrosine residues and plays an important role in cell life. Excessive inflammation can damage normal tissues, leading to organ dysfunction and irreversible structural damage. In recent years, a large number of scientific studies have found that PTP1B plays an indispensable role in tissue inflammation. On the one hand, it regulates the functions of macrophages and microglia through regulating inflammatory signaling pathways; on the other hand, it can affect the apoptosis of tissue cells, and the two jointly promote the occurrence and development of tissue inflammation. This paper will review the role and mechanism of PTP1B in inflammation of different tissues, and lay a theoretical foundation for subsequent studies and the discovery of effective drug targets.
