Molecular mechanism of cisplatin-induced nephrotoxicity and intervention of traditional Chinese medicine
10.3969/j.issn.1001-1978.2020.01.004
- Author:
Lian-Hong YIN
1
Author Information
1. Iiaoning Dalian Medical Unittnilj, College of Pharmacy
- Publication Type:Journal Article
- From:
Chinese Pharmacological Bulletin
2020;36(1):13-18
- CountryChina
- Language:Chinese
-
Abstract:
Cisplatin (DDP) is one of the most commonly used medicines in combination chemotherapy; however, its clinical upplicaiion is greatly limited by nephrotoxicity. In the present paper, the molccular mechanisms including cytotoxicity, oxidative stress, inflammation and apoptosis signaling pathways on DDP-induccd nephrotoxicity were discussed, and the relationship between DDP-induced nephrotoxicity and transporters and raiRNAs was also analyzed. In addilion, recent advances on tra-ditional Chinese medicines (TCMs) for the preventicn and treatment of DDP-induced nephrotoxicity were reviewed, aiming to provide useful information for the research and development of innovative drugs in the treatment of DDP-induced nephrotoxicity. Key words: Cisplatin; nephrotoxicity; cytotoxicity; oxidative stress; inflammation; apoplosis; traditional Chinese medicine.
