Advances in research on notch signaling pathway in pulmonary vascular remodeling of pulmonary arterial hypertension
10.3969/j.issn.1001-1978.2020.01.002
- Author:
Ming-Xing LI
1
Author Information
1. School of Medicine, Zhejiang University, Sir Run Run Shaw Hospital, Dept of Pharmacy, Hangzhou
- Publication Type:Journal Article
- Keywords:
Notch signaling pathway;
Progress;
Pulmonary arterial endothelial cells;
Pulmonary arterial hypertension;
Pulmonary arterial smooth muscle cells;
Pulmonary vascular remodeling
- From:
Chinese Pharmacological Bulletin
2020;36(1):5-8
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary hypertension is a cardiovascular disease characterized by persistent elevation of pulmonary artery pressure and pulmonary vascular resistance, causing pulmonary vascular remodeling. Notch signaling pathway is a highly conserved signaling pathway involved in the occurrence and development of cardiovascular, neurological and tumor diseases mainly by regu-lating cell proliferation, differentiation and apoptosis. TTiis paper mainly reviews the molecular mechanism of Notch signaling path way involved in pulmonary vascular remodeling, contributing to provide a new strategy for the treatment of pulmonary arterial hypertension.
