Effect of antidepressant puyu capsule on sexual l function of male rats and its mechanism
10.3969/j.issn.1001-1978.2020.02.025
- Author:
Ru JIA
1
Author Information
1. Dept of Pharmacy
- Publication Type:Journal Article
- Keywords:
5-ht;
5-htia receptor;
Androgen;
Antidepressants;
Puyu capsule;
Sexual function
- From:
Chinese Pharmacological Bulletin
2020;36(2):282-288
- CountryChina
- Language:Chinese
-
Abstract:
Aim To evaluate the effect of PuYu Cap-sule on sexual function in male rats in comparison to that of mirtazapine and SSRI antidepressant fluoxetine, so as to explore the pharmacological features of PuYu Capsule. Methods Sixty male rats were divided into control group, fluoxetine group, mirtazapine group, PuYu Capsule of high, medium and low dose group. After repeated administration of PuYu Capsule, the effects of the drugs on sexual function of male rats were verified by the mating behavior model and non-contact behavior model of rats. After repeated administration of PuYu Capsule, WAY100635 and buspirone were added respectively to verify the mating behavior model and non-contact behavior model. Furthermore, the effects of PuYu Capsule on rat androgen were verified by rat androgen ELISA kit after chronic administration. Re-suits In the mating behavior test and non-contact penile erection experiment of male rats, PuYu Capsule yielded no effect on the sexual function of male rats. WAY100635 and buspirone reversed the sexual dysfunction induced by fluoxetine, but had no effects on other medicines. None of the medications had any effect on androgen. Conclusions PuYu Capsule has no significant effect on androgen and sexual function of male rats, which is better than that of fluoxetine. The antidepressant mechanism of PuYu Capsule may be that it does not affect 5-HT.
