The Effects of On-line Hemodiafiltration on Oxidative Stress and beta2-Microglobulin in Comparison with High-Flux Hemodialysis.
- Author:
Hyun Jin KIM
1
;
Dong Ki KIM
;
Hyung Jong KIM
;
Dong Ryeol RYU
;
Shin Wook KANG
;
Kyun Hun CHOI
;
Ho Yung LEE
;
Dae Suk HAN
;
Ea Wha KANG
;
SuK Kyun SHIN
;
Eun Jin JUNG
;
Yang Sook PARK
Author Information
1. Department of Internal Medicine, Samsung Medical Center, College of Medicine, Sungkyunkwan University, Korea.
- Publication Type:Original Article
- Keywords:
Hemodiafiltration;
Malondialdehyde;
C-reactive protein;
Oxidative stress;
beta2-microglobulin
- MeSH:
C-Reactive Protein;
Dialysis;
Hemodiafiltration*;
Humans;
Malondialdehyde;
Membranes;
Oxidative Stress*;
Renal Dialysis*;
Urea
- From:Korean Journal of Nephrology
2005;24(2):255-264
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: On-line hemodiafiltration (OL-HDF) is a method that combines diffusive and convective solute transport component. OL-HDF provides improved solute clearance for both low-and large molecular-weight uremic toxins by enhancing convective clearance through highly permeable membranes. The aim of this study is to evaluate the effect of OL-HDF on oxidative stress and beta2-microglobulin (beta2-MG) in comparison with high-flux hemodialysis (HF-HD). METHODS: Twenty-one patients on thrice-weekly low-flux hemodialysis (LF-HD) for at least 6 months were studied. Every patient underwent OL-HDF and HF-HD for four weeks, respectively. There were 2 weeks of wash-out period in which patients were treated with LF-HD, between different treatment periods. Predialysis and postdialysis solute (creatinine, BUN, phosphate, beta2-MG) concentrations were measured in the serum. In addition, predialysis solute (MDA, TAC, hsCRP) concentrations were measured. RESULTS: The urea reduction ratio (64.2+/-14.5 vs. 60.1+/-11.2%), Kt/V (1.4+/-0.2 vs. 1.3+/-0.3), beta2-MG reduction ratio (53.8+/-9.7 vs. 44.3+/-8.7%) and beta2- MG clearance (120.7+/-33.4 vs. 92.7+/-17.6 mL/min) were significantly higher in patients treated with on- line HDF compared with those treated with HF-HD. After 4 weeks of treatment, predialysis serum MDA levels were significantly lower in patients treated with OL-HDF compared with those treated with HF-HD (1.04+/-0.26 vs. 1.19+/-0.25 umol/L). After 4 weeks of treatment with 2 different dialysis modes, predialysis serum beta2-MG (3.7+/-1.0 vs. 2.2+/-0.4 mg/ dL), MDA (1.19+/-0.21 vs. 1.04+/-0.26 umol/L), TAC (265.9+/-21.1 vs. 290.2+/-23.9 umol/L) and log hsCRP (0.07+/-0.51 vs. -0.23+/-0.62) levels were significantly improved compared to the baseline in OL-HDF patients. However, for HF-HD patients, only predialysis serum beta2-MG level at 4 weeks was significantly lower than baseline (3.8+/-1.0 vs. 2.5+/-0.4 mg/dL). CONCLUSION: This study shows that OL-HDF has been significant increase in oxidative stress and inflammatory marker removal compared to HF-HD.
