Analgesic effects of aspirin combined with kv7 channel openers
10.3969/j.issn.1001-1978.2020.02.022
- Author:
Jia-Yu ZHANG
1
Author Information
1. Second Clinical Medical School
- Publication Type:Journal Article
- Keywords:
Analgesic effect;
Aspirin;
Drug combination;
Flupirtine;
Kv7 channel;
Retigabine
- From:
Chinese Pharmacological Bulletin
2020;36(2):267-270
- CountryChina
- Language:Chinese
-
Abstract:
Aim To provide scientific evidence for clinical drug combination by exploring the analgesic effect of aspirin combined with Kv7 channel openers, retigabine and flupirtine. Methods The mice were randomly divided into control group, aspirin group, flupirtine group, retigabine group, aspirin + flupirtine group and aspirin + retigabine group. To assess the antinociceptive effects of each group, the acetic acid-induced abdominal constriction test and the hot-plate test were used. Results In the acetic acid-induced abdominal constriction test, compared to aspirin group, the amount of abdominal constriction in aspirin + flupirtine group was significantly reduced (P <0.01). The latent period of abdominal constriction in aspirin + retigabine group was significantly prolonged ( P < 0. 01) and the number of abdominal constriction was significantly reduced (P < 0. 01). In the hot-plate test, compared to aspirin group, the increment percentage of latent period in aspirin + flupirtine group and aspirin + retigabine group showed an increased trend. Among them, the increment percentage of latent period 30 and 60 minutes after injections in aspirin + retigabine group had a significant difference from that in aspirin group (P <0. 05). Conclusion Kv7 channel openers, retigabine and flupirtine, can enhance the analgesic effect of aspirin.
