Research progress of signaling transduction pathway mediated by tgr5
10.3969/j.issn.1001-1978.2020.02.002
- Author:
You-Chao QI
1
,
2
Author Information
1. Coll. of Vet. Medicine
2. Key Lab of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture
- Publication Type:Journal Article
- Keywords:
Akt;
Camp;
Err;
Nf-kb;
Stat3;
Tgr5
- From:
Chinese Pharmacological Bulletin
2020;36(2):153-157
- CountryChina
- Language:Chinese
-
Abstract:
GPCBAR1, also known as TGR5 receptor, is one member of the GPCRs family. TGR5, a pattern recognition receptor located on cell membrane, is widely expressed in human beings and animals, playing numerous significant roles in anti-inflammation and immune regulation, energy metabolism, glucose metabolism and anti-cancer. Many signaling pathways are induced by TGR5 upon activated. AKT, NF-kB, ERK, STAT3, cAMP signaling pathways, methods and results of TGR5-mediated signaling pathways and t(ie development of new drugs via TGR5-mediated signaling pathways were reviewed in this paper.
