Effect of active peptides of Eupolyphaga on intestinal flora in rats with hyperlipemia
10.3969/j.issn.1001-1978.2020.05.007
- Author:
Shao-Ping WANG
1
Author Information
1. School of Pharmacy, Binzhou Medical University
- Publication Type:Journal Article
- Keywords:
16rS high-throughput sequencing technology;
Active peptide of Eupolyphaga;
Blood lipid;
HE staining;
Hyperlipidemia;
Intestinal flora
- From:
Chinese Pharmacological Bulletin
2020;36(5):621-626
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of active peptide of Eupolyphaga (APE) on changes of intestinal flora and blood lipid in rats with hyperlipidemia. Methods SD rats fed with high-fat diet were induced to hyperlipemia model. Simvastatin being a positive drug, ELISA was used to investigate the effect of APE on blood lipids in hyperlipidemic rats. At the same time, the results of the microbial flora about APE model rats were measured using 16rS high-throughput assay technology (V4-V5). Results APE could significantly reduce the serum lipid index in model rats and improve the degree of liver pathological changes. Meanwhile, the intestinal flora results showed that when the relative abundance of hymenoscyphus, lactobacillus and bifidobacterium in firmicutes were enriched, the relative abundances of rumenococcus, plasmodium and prevotella in bacteroidetes and tenericutes were reduced. Conclusions APE could obviously reduce the level of blood lipid and repair the disordered intestinal flora of hyperlipidemia rats. It can be speculated that APE might play a role in lowering blood lipids through the intervention of lipid metabolism pathway by intestinal flora.
