Research progress on the role of extracellular vesicles in bacterial pathogenesis
10.7507/1002-1892.201805075
- Author:
Shangchun GUO
1
Author Information
1. Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital
- Publication Type:Journal Article
- Keywords:
exosomes;
Extracellular vesicles;
gram-negative bacteria;
gram-positive bacteria;
infection;
pathogenic mechanism
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2018;32(12):1597-1604
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To summarize the bioactive substances contained in bacterial extracellular vesicles (EVs) and their mechanisms in mediating bacterial-bacterial and bacterial-host interactions, as well as their mechanisms for use in implant infection-associated clinical guidance. Methods: A wide range of publications on bacterial-derived EVs were extensively reviewed, analyzed, and summarized. Results: Both gram-negative bacteria (G - bacteria) and gram-positive bacteria (G + bacteria) can secrete EVs which contain a variety of bioactive substances, including proteins, lipids, nucleic acids, and virulence factors, and mediate bacterial-bacterial and bacterial-host interactions. EVs play an important role in the pathogenic mechanism of bacteria. Conclusion: Bioactive substances contained within bacteria-derived EVs play an important role in the pathogenesis of bacterial infectious diseases. In-depth study and understanding of their pathogenic mechanisms can provide new insights which will improve early clinical diagnosis, prevention, and treatment of implant-associated infection. However, at present, research in this area is still in its infancy, and many more in-depth mechanisms need to be further studied.
