The Effects of Moxifloxacin in Endotoxin-induced Acute Lung Injury.
- Author:
Jong Hyun BAEK
1
;
Jang Hoon LEE
;
Jung Cheul LEE
;
Dong Hyup LEE
;
Yong Suk MOON
;
Young Man LEE
Author Information
1. Department of Thoracic and Cardiovascular Surgery, College of Medicine, Yeungnam University, Korea. heartljh@med.yu.ac.kr
- Publication Type:Original Article
- Keywords:
Acute respiratory distress syndrome;
Neutrophils;
Phospholipase A
- MeSH:
Acute Lung Injury;
Animals;
Aza Compounds;
Bronchoalveolar Lavage Fluid;
Cytosol;
Light;
Lung;
Malondialdehyde;
Neutrophils;
Peroxidase;
Phospholipases A2, Secretory;
Quinolines;
Rats;
Respiratory Distress Syndrome, Adult;
Sepsis
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2009;42(1):1-8
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The pathophysiology of acute respiratory distress syndrome with sepsis is acute lung injury (ALI) that's' caused by endotoxin (LPS). We evaluate effects of moxifloxacin on LPS-induced ALI in a rat model. MATERIAL AND METHOD: The rats were divided into 3 groups as the control group (C), the LPS insult group (L), and the LPS+moxifloxacin treated group (L-M). ALI was induced by endotracheal instillation of E.coli LPS, then moxifloxacin was given in 30 minutes. Five hours later, we checked the lung weight/body weight ratio(the L/BW ratio), the protein & neutrophils in the bronchoalveolar lavage fluid (BALF), the myeloperoxidase (MPO) activity & the malondialdehyde (MDA) content, the expressions of cytosolic and secretory phospholipase A2 (c, sPLA2), and the morphology of the lung with using a light microscope. RESULT: The L/BW ratio, the protein content and the neutrophil count in the BALF, and the MPO activity and the MDA content in lung were significantly increased in group L compared to group C, and these factors were markedly decreased in group L-M compare to group L. The cPLA2 expression and the sPLA2 expression were increased in group L and the cPLA2 expression was decreased in group L-M. Yet the sPLA2 expression was not changed in group L-M. Morphologically, many inflammatory findings were observed in group L, but not in group L-M. CONCLUSION: Many of the inflammatory changes of ALI that were caused by LPS insult were ameliorated by moxifloxacin treatment.
