Efficacy of intervention with simvastatin and aspirin for carotid arteriosclerosis in patients with hypertension
- Author:
Hua-Sheng PENG
1
Author Information
1. Department of Neurology
- Publication Type:Journal Article
- From:
Chinese Journal of Cerebrovascular Diseases
2006;3(1):15-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the efficacy of sinivastatin and aspirin as well as blood pressure controlling therapy for carotid atherosclerosis in patients with hypertension. Methods: 162 patients with essential hypertension and carotid atherosclerosis were randomized into two groups. 82 cases In the treatment group, were treated with simvastatin and aspirin as well as antihypertensive drugs; while 80 cases in the control group were treated with antihypertensive drugs alone. Intima-media thickness (IMT) of carotid arterial, carotid plaques score, blood pressure and the serum lipids were measured before and once a year after treatment for 3 years. Results: Mean IMT of carotid artery and carotid plaques score were (1.01 ± 0.12) mm and 3.8 ± 2.5 respectively in the treatment group 1 year a fter treatment, showed no difference from that before treatment. But they were (0.80 ± 0.16) mm, 2.6 ± 1.6 and (0.80 ± 0.20) mm, 2.5 ± 1.2 after 2 and 3 years respectively, which were reduced significantly compared with that of before treatment. The IMT and internal diameter ratio was also reduced significantly after treatment. Overall incidence of cardio-and cerebro-vascular events in the treatment group were 10.90% and 4.87% during the 3 years follow-up period, which were significantly lowered compared to the control group. Conclusion: Long-term simvastatin and aspirin therapy could effectively delay and reverse the progression of carotid arteriosclerosis in patients with hypertension and prevent cardio-and cerebro-vascular events when combined with antihypertensive drugs.
