Detecting internal carotid artery stenosis by using the cerebral blood flow reduction index in rabbit mode
- Author:
Gong WU
1
Author Information
1. Department of Neurology
- Publication Type:Journal Article
- From:
Chinese Journal of Cerebrovascular Diseases
2006;3(4):168-172
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To establish an experimental unilateral internal carotid artery stenosis model in New Zealand albino rabbits that can be detected in vivo. Methods: A 2 F Foley's tube was inserted into unilateral carot id artery for performing intimal injury in 5 rabbits, and causing intimal hyperplasia and angiostenosis. The hemodynamic changes of unilateral carotid artery were detected by transcranial Doppler (TCD); the reduction of cerebral blood flow (CBF) after stenosis was calculated by mathematical formulas. The degree of stenosis was confirmed by digital subtraction angiography (DSA), and the arterial intimal hyperplasia and stenosis were confirmed by pathological examination. Results: Two rabbits survived after the procedure. TCD, DSA and pathological examination showed that the model of experimental unilateral internal carotid artery stenosis in rabbits was established successfully. The reduction of CBF after unilateral internal carotid artery stenosis was calculated in the 2 rabbits, they were 17% and 45%, respectively. Conclusion: The rabbit model of unilateral internal carot id artery stenosis has been established successfully, and the severity of stenosis can be detected and evaluated in vivo.
