Clinical significance of plasma MMP-9, VEGF and vWF in patients with cerebral infarction
- Author:
Bao-Shan GAO
1
Author Information
1. Department of Neurosurgery
- Publication Type:Journal Article
- From:
Chinese Journal of Cerebrovascular Diseases
2006;3(8):365-368
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To discuss the clinical significance of plasma von Willebrand factor (vWF), vascular endothelial growth factor (VEGF), and matrix metalloproteinase-9 (MMP-9) in patients with cerebral infarction in the process of occurrence and development of cerebral infarction. Methods: Thirty patients with cerebral infarction were divided into 3 groups according to their size of infarction: large infarction, moderate infarction, and small infarction (ten patients in each group). Enzyme-linked immunoadsordent assay (ELISA) was used to detect the concentrations of plasma vWF, VEGF, and MMP-9 in patient with cerebral infarction and in 20 healthy controls on day 1, 3, 7, and 15. Results: The mean levels of vWF (216 ± 62) μg/L, VEGF (584 ± 151) ng/ L, and MMP-9 (287 ± 147) μg/L in the cerebral infarction groups were significantly higher than those in the control group [vWF (96 ± 12) μg/ L, VEGF (111 ± 17) ng /L, and MMP-9 (102 ± 14) μg/L; P < 0.01]. The changes of plasma concentrations of the above 3 factors were correlated positively with the volume of cerebral infarction at the same time point in early cerebral infarction (r = 0.496, r = 0.519, r = 0.472 respectively; all P < 0.01). Conclusion: The concentrations of plasma vWF, VEGF, and MMP-9 were associated with the volume of cerebral infarction.
