Comparative study of risk factors for early and advanced atherosclerosis
10.3969/j.issn.1672-5921.2011.04.006
- Author:
Jian-Jun GUI
1
Author Information
1. Department of Neurology
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Carotid arteries;
Cerebrovascular disorders;
Cholesterol;
HDL;
Lipoproteins;
Risk factors
- From:
Chinese Journal of Cerebrovascular Diseases
2011;8(4):189-194
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The purpose of this study is to compare the risk factors for the two different atherosclerosis processes, namely the early atherosclerosis and advanced atherosclerosis. Methods: Using magnetic resonance angiography and high-resolution B-mode ultrasonography, 92 patients with advanced atherosclerosis (atherosclerotic cerebral infarction/transient ischemic attack) and 120 patients with early atherosclerosis (no cardiovascular and cerebrovascular diseases and carotid stenosis <40% on B-mode ultrasonography) were included. The difference and similarity of the risk factors for early atherosclerosis and advanced atherosclerosis were compared respectively using the binary logistic regression. Results: In the binary logistic model of carotid plaque formation, the traditional risk factors, such as age (years) (OR, 1.101, 95% CI: 1.046-1.159, P < 0.001), high TC (OR, 2.236, 95% CI: 0.821-6.089, P = 0.0115), hypertension (OR, 2.623, 95% CI: 0.989-6.957, P = 0.053), and smoking (%) (OR, 7.975, 95% CI: 2.274-27.9651, P =0.001) were the statistically significant independent variables. In the binary logistic model of advanced atherosclerosis, male (OR, 2.064, 95% CI: 1.137-0.748, P = 0.017), high Lp (a) (OR, 2.818, 95% CI: 1.499-5.298, P=0.001), low HDL (OR, 2.451, 95%CI: 1.234-4.868, P=0.010), and diabetes mellitus (OR, 2.414, 95% CI: 1.232-4.731, P=0.010) were the statistically significant independent variables. Conclusion: The risk factors for advanced atherosclerosis and early atherosclerosis are different, diabetes mellitus and lipoprotein (a) may play an important role in the advanced atherosclerosis.
