Relationship between G505A polymorphism in the encoding region of thrombin-activated fibrinolysis inhibitor and cerebral infarction
10.3969/j.issn.1672-5921.2012.01.007
- Author:
Fang-Mei HE
1
Author Information
1. Department of Neurology
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Genes;
Polymorphism, single nucleotide;
Thrombin-activated fibrinolysis inhibitor
- From:
Chinese Journal of Cerebrovascular Diseases
2012;9(1):32-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between G505A polymorphism in the encoding region of thrombin-activated fibrinolysis inhibitor (TAFI) and cerebral infarction in Chinese Han population. Methods: A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect G505A polymorphism in the encoding region of TAFI in 130 patients with cerebral infarction and 118 healthy individuals. Results: The GG genotype of TAFI G505A accounted for 35.4% (46/130) and GA or AA genotype accounted for 64.6% (84/130) in the cerebral infarction group; and they were 49.2% (58/118) and 50.8% (60/118) respectively in the control group. The difference was statistically significant (P = 0.028). The G and A allele frequencies were 60.4% (157/260) and 39.6% (103/260) respectively in the cerebral infarction group, and they were 69.9% (165/236) and 30.1% (71/236) respectively in the control group. The difference was statistically significant (P = 0.026). Multivariate logistic regression analysis showed that G505A polymorphism in the encoding region of TAFI was an independent risk factor for cerebral infarction (OR = 2.660, 95% CI 1.330-5.317, P = 0.006). Conclusion: The TAFI G505A polymorphism may be one of the risk factors for cerebral infarction.
