Clinical significance of serum cystatin C in patients with acute ischemic stroke
10.3969/j.issn.1672-5921.2012.01.006
- Author:
Ming YE
1
Author Information
1. Department of Neurology
- Publication Type:Journal Article
- Keywords:
Bain ischemia;
Clinical study;
Cystaine proteinase inhibitors;
Stroke
- From:
Chinese Journal of Cerebrovascular Diseases
2012;9(1):27-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the correlation and clinical significance of serum cystatin C (Cys-C) level and ischemic stroke. Methods: A total of 147 patients with acute ischemic stroke were recruited. They were divided into small, medium and large sub-groups according to the infarct volume of the brain. They were also divided into high-risk group (the National Institute of Health Stroke Scale > 8) and low-risk group (NIHSS≤8) according to the scores of NIHSS. Sixty patients without stroke were selected as a control group. A particle enhanced immunoturbidimetric assay was used to detect the serum Cystain C levels, investigate the relationship between Cystain C level and ischemic stroke and analyze the correlation between Cystain C level. Results: Circled digit oneThe serum Cystain C level 1.20 ± 0.40mg/L in the ischemic stroke group was significantly higher than 0.86 ± 0.23 mg/L in the control group. The difference was statistically significant (P < 0.05). With the increase in infarct volume, the serum Cystain C level also increased. The difference was statistically significant (P < 0.05). Circled digit twoThe serum Cystain C level 1.33 ± 0.52 mg/L in a stroke recurrence group was higher than 1.12 ± 0.28 mg/L in a initial stroke group. The difference was statistically significant (P < 0.01). Circled digit threeThe serum Cystain C level has no correlation with the NIHSS score, but the serum Cystain C level 1.37 ± 0.68 mg/L in the high risk group was higher than 1.15 ± 0.27 in the low risk group. The difference was statistically significant (P < 0.01). Circled digit fourThe serum Cystain C level was positively correlated with homocysteine (Hcy) (r = 0.189, P = 0.022) and very low density lipoprotein cholesterol (VLADL-C) (r = 0.255, P = 0.002), however, it was negatively correlated with high density lipoprotein cholesterol (HDL-C) (r = -0.173, P = 0.036). Circled digit fiveMultivariate logistic regression analysis showed that the serum Cystain C was a risk factor for ischemic stroke (OR = 2.646, 95% CI 1.621-4.317, P < 0.01). Conclusion: The increased serum Cystain C level is an independent risk factor for ischemic stroke, it is associated with the lesion size and the severity of cerebral infarction. The serum level may be used as a reference indicator for the occurrence and development of cerebral infarction and disease surveillance.
