Advance in predisposing factors for moyamoya disease
10.3969/j.issn1672-5921.2019.02.009
- Author:
Pengyu GUO
1
Author Information
1. Department of Physiology and Neurobiology, Sino-UK Joint Laboratory for Brain Function, Injury of Henan Province, Xinxiang Medical University
- Publication Type:Journal Article
- Keywords:
Cellular environmental;
Genetic;
Immunity;
Moyamoya disease;
Pathogenesis;
Review
- From:
Chinese Journal of Cerebrovascular Diseases
2019;16(2):101-108
- CountryChina
- Language:Chinese
-
Abstract:
Moyamoya disease ( MMD) is a progressive cerebrovascular disease with characteristics of ethnic susceptibility and familial aggregation. The pathological changes of slenosed vessels in MMD includc intima thickening,tunica media thinning,irregular undulation of the internal elastic laminae and lymphocytic infiltration The etiology and pathogenesis arc not completely clarified. It is presently thought that this disease is related to endothelial cells,smooth muscle cells,abnormal metabolism of extracellular matrix and inflammatory responses. This review will discuss,from genetic.cellular environmental and immunological perspectives,the specific roles of several genes in the development of MMD, including endothelial cell susceptibility gene ring finger protein 213,smooth muscle ccll susceptibility genes,extracellular matrix genes,angiogenesis factors and immune-related genes.
