Roles and mechanisms of adenosine monophosphate activated protein kinase in cerebral ischemia
10.3969/j.issn.1672-5921.2019.09.009
- Author:
Jiaqi JIANG
1
Author Information
1. Institute of Neuroscienees, Department of Neurology, Second Affiliated Hospital, Guangzhou Medical University
- Publication Type:Journal Article
- Keywords:
Adenosine monophosphate activated protein kinase;
Cerebral ischemia;
Energy metabolism;
Oxidative stress;
Review
- From:
Chinese Journal of Cerebrovascular Diseases
2019;16(9):490-494
- CountryChina
- Language:Chinese
-
Abstract:
Adenosine monophosphate activated protein kinase(AMPK) is a highly conserved serine/threonine protein kinase which plays an important role in regulating energy metabolism. After cerebral ischemia and hypoxia, AMPK is activated. The activation of AMPK could decrease neurological impairment after cerebral ischemia and plays a neuroprotective role by mechanisms such as inhibiting oxidative stress and inflammation, activating autophagy, alleviating apoptosis and promoting angiogenesis. This article reviews the molecular biological characteristics of AMPK and its role and mechanism in cerebral ischemia, aiming to promote an in-depth study of AMPK and make it a novel target for the treatment of ischemic stroke.
