Factors for rupture of intracranial aneurysms with parent artery stenosis: A preliminary analysis
10.3969/j.issn.1672-5921.2019.11.001
- Author:
Zhiwen LU
1
Author Information
1. Department of Neurosurgery, First Hospital Affiliated to the Naval Military Medical University
- Publication Type:Journal Article
- Keywords:
Hemodynamics;
Intracranial aneurysm;
Parent artery stenosis;
Rupture risk
- From:
Chinese Journal of Cerebrovascular Diseases
2019;16(11):561-565
- CountryChina
- Language:Chinese
-
Abstract:
Objective To preliminarily analyze the risk factors for rupture of intracranial aneurysms combined with proximal parent artery stenosis. Methods From June 2016 to December 2018, 52 admitted patients with intracranial aneurysms combined with proximal parent artery atherosclerotic stenosis and admitted in Neurosurgery Department of First Hospital Affiliated to Naval Military Medical University were enrolled. All patients were diagnosed by DSA. The 52 patients were divided into the ruptured group and the unruptured group, with each group containing 26 patients. The baseline data, 3D DSA data, morphology and hemodynamic parameters of intracranial aneurysms with parent artery stenosis were collected and compared between the two groups. The baseline data included age, gender, prior history of hypertension, smoking, diabetes, cerebral infarction, oculomotor palsy and multiple aneurysms. 3 D DSA data included degree of stenosis (mild to severe). Morphological and hemodynamic parameters included normalized wall shear stress (NWSS), percentage of low wall shear stress area (LSA), aspect ratio (AR), distance of stenosis, size ratio (SR) and degree of stenosis (quantitative index). Results (1) The proportion of female in the ruptured group was higher than that in the unruptured group (80.8% [21/26] vs. 53. 8% [14/26] , χ2 =4. 282, P = 0. 039). There was no difference in ypertension, diabetes, smoking history, multiple aneurysms, cerebral infarction and oculomotor paralysis between the two groups (all P >0. 05). (2) There was no difference in the degree of stenosis (mild to severe) between the two groups (P > 0.05). (3) The ruptured group had lower NWSS than that of the unruptured group, but higher LSA and AR(0.691 [0. 560, 0. 867] vs. 0.852 [0.701, 1.097], Z = -2. 397; 7. 91% [1.28%, 11. 94%] vs. 1.36%[0.28%, 3.48%], Z = 2.581;[1. 1 ±0. 3] vs. [0. 9 ±0.4], t =2.751; all P < 0. 05). There was no significant difference in distance of stenosis, SR and the degree of stenosis (quantitative index) between the two groups (all P >0. 05). Conclusion Female, high LSA, high AR and low NWSS may have an impact on the rupture of intracranial aneurysms with parent artery stenosis.
