A surey of bioanalysis methods for antibody drugs
10.12092/j.issn.1009-2501.2020.02.017
- VernacularTitle: 抗体类药物的生物分析方法研究概况
- Author:
Fengjia ZHENG
1
Author Information
1. School of Chemical Engineering and Technology, Tianjin University
- Publication Type:Journal Article
- Keywords:
Bioanalytical methods;
Flow cytometry;
LC-MS/MS;
Monoclonal antibody
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(2):227-232
- CountryChina
- Language:Chinese
-
Abstract:
Antibody drugs have become the first choice for clinical treatment of many diseases due to their advantages of targeting, high specificity and low toxicity. However, the disposal mechanism in vivo has its particularity and complexity, which greatly increases the difficulty of biological detection. Therefore, to establish the sensitive, accurate and repeatable methods is urgent. This paper mainly focuses on the bioanalytical methods of this kind of drugs, introduces the characteristics and application of enzyme-linked immunosorbent assay, electrochemiluminescence, liquid chromatography-mass spectrometry, flow cytometry and some new techniques, in hope of providing a reference for the study of related drugs.
