Role of autophagy in islet β cells: A novel target for diabetes’ therapy
10.12092/j.issn.1009-2501.2020.03.016
- VernacularTitle: 从自噬在胰岛β细胞中的作用探讨糖尿病治疗的药物靶点
- Author:
Chuting LI
1
Author Information
1. Department of Pharmacy, Xiangya Hospital, Central South University
- Publication Type:Journal Article
- Keywords:
Anti-diabetic medications;
Autophagy;
Diabetes mellitus;
Drug targets;
Islet β cell;
Signaling pathway
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(3):344-351
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a catabolism process in which lysosomes degrade damaged organelles, protein aggregates and recover nutrients. Studies have shown that autophagy could protect the structure and function of islet β cell and maintaining normal secretion of insulin. In addition, autophagy plays important roles in the occurrence and development of diabetes mellitus by reducing oxidative stress, preventing apoptosis and removing ubiquitination protein aggregates. Therefore, autophagy may be a new target for the prevention and treatment of diabetes. At present, hypoglycemic drugs have been proved to play positive roles by regulating autophagy including thiazolidine dione and guanidine. Therefore, this paper will review autophagy definition, the role of autophagy in diabetes mellitus and autophagy-related hypoglycemic drugs, providing a new direction for clinical treatment of diabetes.
