Pharmacological targets and clinical application of traditional Chinese medicine and active components in the prevention and treatment for depression
10.12092/j.issn.1009-2501.2020.04.018
- VernacularTitle: 中药及其活性成分防治抑郁症的药理靶点与临床应用
- Author:
Rui FENG
1
Author Information
1. Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Key Laboratory (Theory and Therapy of Muscles and Bones) of Ministry of Education
- Publication Type:Journal Article
- Keywords:
Action target;
Depression;
Signaling pathway;
Traditional Chinese medicine;
Transcriptional factor
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(4):467-474
- CountryChina
- Language:Chinese
-
Abstract:
The pathological mechanism for depression is complicated due to the involvement of types of transcriptional factors and signaling pathways in the occurrence and development of depression. Traditional Chinese medicine (TCM) characterized with multi-components and multi-targets exert unique advantage in the prevention and treatment of depression. This review summarized the pharmacological action of TCM and active components on transcriptional factors (CREB, NF-κB, Nrf2) and signaling pathways (BDNF-TrkB, MAPK, GSK-3β, TLR-4-NLRP3-IL-1β) as well as elucidated the clinical application of TCM formula in the prevention and treatment for depression based on relevant literatures from home and abroad.
