Effects of atorvastatin and folic acid tablets on homocysteine and carotid atherosclerosis in patients with type H hypertension
10.12092/j.issn.1009-2501.2020.04.016
- VernacularTitle: 叶酸片联合阿托伐他汀治疗对H型高血压患者同型半胱氨酸及颈动脉粥样硬化的影响
- Author:
Xiangmei XIE
1
Author Information
1. Northern Guangdong people's Hospital
- Publication Type:Journal Article
- Keywords:
Atorvastatin;
Carotid atherosclerosis;
Folic acid tablets;
Homocysteine;
Type H hypertension
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(4):455-459
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To analyze the effects of atorvastatin and folic acid tablets on homocysteine and carotid atherosclerosis in patients with type H hypertension. METHODS: A total of 140 patients with H-type hypertension admitted to our hospital from January 2016 to October 2018 were enrolled in the study. Random number table method was divided into observation group (70 cases) and control group (70 cases). The control group was treated with folic acid tablets on the basis of routine blood pressure reduction. The observation group was given atorvastatin calcium tablets on the basis of the control group, and the treatment was 10 weeks. Comparing the two groups of homocysteine, low-density lipoprotein, brachial-ankle pulse wave velocity, carotid intima-media thicknessbefore and after treatment, blood pressure and heart rate levels, and observed the occurrence of adverse reactions. During a follow-up of one year, the incidence of cardiovascular and cerebrovascular events was compared between the two groups. RESULTS:The plasma Hcy level and LDL level in the observation group was significantly lower than that in the control group (P<0.05). There was significant difference in BaPWV and IMT between the two groups (P<0.05). After treatment, the systolic and diastolic blood pressures of the two groups were treated. The systolic blood pressure and diastolic blood pressure were significantly lower than those in the control group (P<0.05), but there was no significant difference in heart rate between the two groups after treatment (P>0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). CONCLUSION:Atorvastatin combined with folic acid tablets can effectively reduce carotid atherosclerosis in patients with type H hypertension, and it can reduce the levels of Hcy and LDL, and it is clinically safe.
