microRNA and drug-induced liver injury
10.12092/j.issn.1009-2501.2020.07.013
- VernacularTitle: microRNA与药物性肝损伤
- Author:
Lina XU
1
Author Information
1. College of Pharmacy, Dalian Medical University
- Publication Type:Journal Article
- Keywords:
Drug target;
Drug-induced liver injury;
MicroRNA;
Regulation function and mechanism
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(7):803-809
- CountryChina
- Language:Chinese
-
Abstract:
The liver is one of the most important organs in human body, which participates in metabolism and detoxification. The liver is easily affected by various drugs and their metabolites. Drug-induced liver injury, also known as drug-induced liver disease, refers to the liver damage or allergic reaction to liver caused by drugs and their metabolites. MicroRNA (miRNA) is a kind of small non-coding RNA, which plays an important regulatory role in many diseases. In this review, the effects and mechanisms of miRNAs in drug-induced liver injury were summarized.
