Function and regulation of miRNAs associated with Parkinson's disease
10.12092/j.issn.1009-2501.2020.07.009
- VernacularTitle: 帕金森氏病关联miRNAs的功能和调控
- Author:
Chenyu LU
1
Author Information
1. Institute of Primate Translational Medicine, Kunming University of Science and Technology
- Publication Type:Journal Article
- Keywords:
Biomarkers;
MiRNA;
Parkinson's disease;
Treatment
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(7):775-783
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease (PD) is a common neurological degenerative disease in the elderly people. The causes of PD are complicated, and its pathogenesis is still unknown. At present, it is generally believed that the occurrence of PD is related to multiple factors such as environment, genetics and age. microRNAs (miRNAs) are endogenous small non-coding RNAs that are involved in regulating about one-third of genes in the human genome at post-transcription level. A large number of studies have shown that miRNAs play important roles in PD. This review discusses recent researches on miRNAs relevant to PD, and summarizes the specific expression of miRNAs in the pathogenesis and diagnosis of PD.
