Targeting DNA damage response in tumor therapy
10.12092/j.issn.1009-2501.2020.08.014
- VernacularTitle: 肿瘤治疗中靶向DNA损伤反应
- Author:
Wenchao ZHAO
1
Author Information
1. Key Laboratory of Molecular Radiation Oncology Hunan Province, Xiangya Hospital of Central South University
- Publication Type:Journal Article
- Keywords:
Chemoresistance;
DNA damage;
Oncotherapy
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(8):943-952
- CountryChina
- Language:Chinese
-
Abstract:
Chemotherapy plays an important role in cancer treatment. With deeply understanding the mechanism of tumorigenesis, different chemotherapeutic drugs have been emerged as initial choices for cancer treatment. However, most patients gradually develop to chemotherapeutic resistance, resulting in failure to initial standard therapy. The mechanisms of chemoresistance are extensively explored. Recent studies indicated intrinsic or acquired alteration of DNA damage repair ability is the key determinant of chemoresistance. In this review, we present deregulation of DNA damage repair pathway in cancers and its involvement contributing to chemoresistance. Furthermore, we discuss strategies to sensitize chemotherapy by targeting at a parallel DNA repair pathway, which become promising approaches to overcome chemotherapeutic resistance.
