Recent updates on drug-resistance mechanisms in Mycobacterium tuberculosis and the role of PE/PPE proteins in drug resistance
10.12092/j.issn.1009-2501.2020.09.013
- VernacularTitle: 结核分枝杆菌耐药机制研究进展和PE/PPE蛋白在介导细菌耐药中的作用
- Author:
Qinglan WANG
1
Author Information
1. National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Publication Type:Journal Article
- Keywords:
Drug mode-of-action;
Mycobacterium tuberculosis;
Outer-membrane channel proteins;
PE/PPE proteins;
Resistance mechanism
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(9):1043-1051
- CountryChina
- Language:Chinese
-
Abstract:
Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (M. tb) and mainly spread by airborne transmission, remains a global health problem. After the wide clinical utilization of antibiotics in treatment of TB, the drug resistance has become a major threat to global TB control and this threat has been heightened by the emergence and propagation of multi-drug resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and totally drug-resistant tuberculosis (TDR-TB). The research in the mode-of-action mechanisms of anti-TB drugs and the drug resistance mechanisms of M. tb will facilitate the novel anti-TB drugs development, the optimization of current anti-TB drugs and the development of new drug resistance diagnosis technologies. This review provides a comprehensive overview of mode-of-action mechanisms of new anti-TB drugs and mechanisms of resistance to these drugs in M. tb, with particular attention to the role of newly-identified mycobacterial outer-membrane channel proteins (PE/PPE proteins) in TB drug resistance.
