Effect of polydatin on IL-1β in serum and protein expression of Bcl-2 in brain tissue of cerebral hemorrhage injured rats
- Author:
Ming LIU
1
Author Information
1. Sir Run Run Shaw Hospital
- Publication Type:Journal Article
- Keywords:
Bcl-2 protein;
Cerebral hemorrhage;
Collagenase VII;
Interleukin-1β;
Polydatin
- From:
Chinese Traditional and Herbal Drugs
2010;41(12):2010-2013
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effects and mechanisms of polydatin on rats with brain hemor-rhagic injury. Methods: The cerebral hemorrhage model in rats was induced by local injection of type VII collagenase and they were randomly divided into six groups. The treated groups were treated with polydatin and Naoxuekang; The normal and control groups were only treated with water. The changes of neuro logical defect were observed. The activity of SOD, the content of MDA, the protein expressions of Bcl-2 in brain tissue, and the contents of IL-1β in serum were measured. Results: Compared with the cerebral hemorrhage model group, polydatin (25, 50, and 100 mg/kg) could significantly reduce the symptoms of neurological deficits of cerebral hemorrhage rats, raise the activity of SOD, reduce the content of MDA, increase the protein expressions of Bcl-2, and decrease the contents of IL-1β in serum. Its effects were pos-itively correlated with the dose-effect. Conclusion: Polydatin has therapeutic effect on rats of cerebral hemorrhage, through against free radical damage and inhibiting neuronal apoptosis and inflammatory.
