Application of solid dispersion combined with carriers for in vitro release of multi-components from Danshen extract
- Author:
Xiu-Li XIONG
1
Author Information
1. Institute of Chinese Medical Sciences
- Publication Type:Journal Article
- Keywords:
Characterization;
Combined carriers;
In vitro release;
Salviae Miltiorrhizae Radix et Rhizoma (Danshen);
Solid dispersion
- From:
Chinese Traditional and Herbal Drugs
2011;42(1):50-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of sole and combined utilizing of carriers to prepare solid dispersion for improving dissolution rate of hydrophilic and lipophilic components in extracts of Salviae Miltiorrhizae Radix et Rhizoma (Danshen). Methods: Solid dispersions were prepared with PVP10 and F127 as sole carrier or their combinations by Spray Drying (SD) method. The prepared powders were characterized by various methods. Three hydrophilic (danshensu, rosmarinic acid, and salvianolic acid B) and two lipophilic components (cryptotanshinone and tanshinone IIA) of Danshen were determined as bioactive markers. The simulating factor (f2) was utilized to evaluate similarities of dissolution profiles of hydrophilic and lipophilic components, respectively. Results: SEM and PXRD results showed that solid dispersion prepared by SD method was amorphous spheroid particles without intensive characteristic peaks. The hydrophilic components were completely released from the bulk Danshen extract and from the prepared solid dispersions. However, no lipophilic components could be completely dissolved from solid dispersions prepared by sole carrier. When combined using carriers (e.g. PVP10-F127 = 5:4), both of the lipophilic and hydrophilic components could be rapidly and completely released from the solid dispersion. Combined use of carriers could increase the wetting angle without changing the specific surface area. Conclusion: The combined use of carriers significantly increases the in-vitro release of lipophilic components in Danshen extract, which: may be attributed to the increased wettability of powders. The simulating factor evaluation results suggest that the release profiles of either the lipophilic or the hydrophilic components in Danshen extract are complete and similar, which could meet the requirements of Chinese Pharmacopoeia.
