Two new triterpene glycosides from Stichopus variegatus
- Author:
Jia-Jia ZHANG
1
Author Information
1. Zhejiang Pharmaceutical College
- Publication Type:Journal Article
- Keywords:
Sea cucumber;
Stichopus variegatus semper;
Triterpene glycoside;
Variegatuside A;
Variegatuside B
- From:
Chinese Traditional and Herbal Drugs
2011;42(1):10-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the constituents from the sea cucumber, Stichopus variegatus. Methods: The crude saponins of S. variegatus were desulfated with pyridine-dioxane (1:1), the desulfated products were separated by multi-chromatography to afford two compounds. Results: On the basis of chemical methods and spectral evidences, especially 2D-NMR and ESI-MS, these two compounds were identified as 3-0-[β-D-xylopyranosyl-(1→2)-4′-O- sulfate-β-D-xylopyranosyl]-holosta-9-ene-3β,12α,17α, 25β-tetraol sodium salt, named as variegatuside A (1) and 16β-acetoxy-3-O-β-D-xylopyranosyl-holosta-22,25-epoxy-9-ene-3β, 12α,17α-triol, named as variegatuside B (2). Conclusion: Compounds 1 and 2 are new compounds.
