Observation of synergistic anti-inflammatory effect of combination of sodium ferulate and oxymatrine
- Author:
Yan SUN
1
Author Information
1. School of Pharmacy
- Publication Type:Journal Article
- Keywords:
Anti-inflammation;
Kushenin;
Nitric oxide (NO);
Oxymatrine (OMT);
Sodium ferulate (SF);
Synergistic effect
- From:
Chinese Traditional and Herbal Drugs
2011;42(3):538-541
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess the synergistic anti-inflammatory effect of sodium ferulate (SF) and kushenin, i.e. oxymatrine (OMT). Methods: The anti-inflammatory effect of the combination of SF and OMT was evaluated on xylene-induced murine ear edema model, carrageenin-induced rat paw edema model, and rat tampon-induced granuloma model in vivo. In vitro, the effect of SF and OMT on the nitric oxide (NO) production induced by LPS was observed on RAW264.7 cells. The content of NO in the supernatant was detected with Griess reagent. Results: When SF was used in combination with OMT, the edema induced by xylene and carrageenin was markedly inhibited, the weight of granuloma caused by tampon was also reduced in the high dose group, and the inhibition rate was more considerable by combined treatment than those by SF or OMT alone. In vitro, the NO production induced by LPS was depressed by combined treatment, and a synergistic anti-inflammatory effect was observed. Conclusion: The present study demonstrate that the combination of SF and OMT could exert conspicuous synergistic anti-inflammatory effect, and the mechanism may be related to the inhibited effect of NO production in inflammatory factors induced by LPS.
