Preparation of β-elemene-polybutylcyanoacrylate nanoparticles
- Author:
Bo WANG
1
Author Information
1. School of Pharmacy
- Publication Type:Journal Article
- Keywords:
β-elemene (β-ELE);
Entrapment efficiency;
Interfacial polymerization;
Nanoparticle (NP);
Polybutylcyanoacrylate (PBCA)
- From:
Chinese Traditional and Herbal Drugs
2011;42(3):474-477
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Optimizing the formula and preparation of β-elemene- polybutylcyanoacrylate nanoparticles (β-ELE-PBCA-NP). Methods: With polybutylcyanoacrylate (PBCA) as the drug-loaded material, β-ELE-PBCA-NP was prepared by interfacial polycondensation. The preparation conditions were optimized by single factor design and the formula was optimized by orthogonal design with entrapment efficiency (EE) as index. EE of β-ELE-PBCA-NP was determinated by RP-HPLC. Results: Under the optimal conditions, the prepared NPs were round and regular in shape without adhesions with average particle size of 254 nm and EE of 90.17%. Conclusion: The optimized technology in this experiment is stable and feasible.
