Preparation of honokiol solid lipid nanoparticles and their characteristic
- Author:
Qing ZHANG
1
Author Information
1. School of Pharmacy
- Publication Type:Journal Article
- Keywords:
Emulsion-evaporation-solidified at low temperature method;
Honokiol;
Orthogonal test;
Solid lipid nanoparticles;
Sustained-release
- From:
Chinese Traditional and Herbal Drugs
2011;42(4):691-693
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare sustained-release honokiol solid lipid nanoparticles (H-SLN). Methods: The solid lipid nanoparticles were prepared by emulsion-evaporation-solidified at low temperature method. The optimum condition was performed based on the orthogonal design to examine the entrapment efficiency, the mean diameter of the particles and the release in vitro. Results: The entrapment efficiency of honokiol in the nanoparticles was 77.1% and the mean diameter of the particles was 159 nm. Conclusion: The emulsion-evaporation- solidified at low temperature method can be used to prepare honokiol solid lipid nanoparticles.
